{"id":57936,"date":"2026-08-05T12:48:34","date_gmt":"2026-08-05T09:48:34","guid":{"rendered":"https:\/\/thesauditimes.net\/en\/?p=57936"},"modified":"2026-08-05T12:48:34","modified_gmt":"2026-08-05T09:48:34","slug":"saudi-arabia-approves-new-oral-obesity-drug-to-expand-weight-loss-treatment-options","status":"publish","type":"post","link":"https:\/\/thesauditimes.net\/en\/saudi-arabia-approves-new-oral-obesity-drug-to-expand-weight-loss-treatment-options\/","title":{"rendered":"Saudi Arabia Approves New Oral Obesity Drug to Expand Weight-Loss Treatment Options"},"content":{"rendered":"<p>Saudi Arabia&#8217;s Saudi Food and Drug Authority (SFDA) has approved the registration of Orforglipron (Foundaio), a new oral medication designed to help adults with obesity or overweight conditions lose weight and maintain long-term weight reduction.<\/p>\n<p>The approval follows a comprehensive scientific review of the drug&#8217;s quality, safety, and effectiveness, based on clinical data and extensive regulatory evaluation.<\/p>\n<h2>Who Can Use the Medication?<\/h2>\n<p>The treatment is intended for:<\/p>\n<ul>\n<li>Adults diagnosed with obesity.<\/li>\n<li>Adults who are overweight and have at least one weight-related medical condition, such as diabetes, hypertension, or cardiovascular disease.<\/li>\n<\/ul>\n<p>The SFDA emphasized that the medication should be used alongside a healthy diet and regular physical activity, rather than as a standalone treatment.<\/p>\n<p>Unlike several other GLP-1 therapies, Orforglipron is administered orally once daily, providing patients with an alternative to injectable medications.<\/p>\n<h2>How Does It Work?<\/h2>\n<p>Orforglipron targets GLP-1 receptors, which play an important role in regulating appetite and blood sugar levels.<\/p>\n<p>By activating these receptors, the medication helps:<\/p>\n<ul>\n<li>Reduce hunger.<\/li>\n<li>Increase feelings of fullness.<\/li>\n<li>Lower food intake.<\/li>\n<li>Support sustained weight loss when combined with lifestyle changes.<\/li>\n<\/ul>\n<h2>Clinical Trial Results<\/h2>\n<p>The approval was supported by two Phase III clinical trials lasting 72 weeks.<\/p>\n<p>The first study involved 3,127 adults with obesity but without diabetes, where participants taking the 36 mg dose achieved an average weight reduction of 11.2%, compared with 2.1% in the placebo group.<\/p>\n<p>The second study included 1,613 adults with obesity and Type 2 diabetes, with participants receiving the same dosage achieving an average 9.6% weight loss, compared to 2.5% for placebo recipients.<\/p>\n<h2>Possible Side Effects<\/h2>\n<p>According to the SFDA, the most commonly reported adverse effects involved the digestive system, including:<\/p>\n<ul>\n<li>Nausea<\/li>\n<li>Diarrhea<\/li>\n<li>Constipation<\/li>\n<li>Vomiting<\/li>\n<li>Indigestion<\/li>\n<li>Abdominal pain and bloating<\/li>\n<li>Fatigue<\/li>\n<li>Hair loss<\/li>\n<\/ul>\n<p>Most side effects were mild to moderate and generally occurred during dose escalation before gradually improving over time.<\/p>\n<h2>Important Safety Warnings<\/h2>\n<p>The SFDA warned that the medication is not suitable for individuals with a personal or family history of certain thyroid cancers or specific inherited endocrine disorders.<\/p>\n<p>The authority stressed that treatment should only be used under medical supervision, with regular follow-up to ensure safety and effectiveness.<\/p>\n<h2>Supporting Saudi Vision 2030<\/h2>\n<p>The approval of Orforglipron expands Saudi Arabia&#8217;s portfolio of advanced obesity treatments and supports the Kingdom&#8217;s healthcare transformation by improving access to innovative therapies for chronic diseases associated with obesity.<\/p>\n<p>The move aligns with Saudi Vision 2030, which seeks to enhance healthcare quality, promote disease prevention, and improve overall public health outcomes.<\/p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Saudi Arabia&#8217;s Saudi Food and Drug Authority (SFDA) has approved the registration of Orforglipron (Foundaio), a new oral medication designed to help adults with obesity or overweight conditions lose weight and maintain long-term weight reduction. The approval follows a comprehensive scientific review of the drug&#8217;s quality, safety, and effectiveness, based on clinical data and extensive regulatory evaluation. Who Can Use the Medication? The treatment is intended for: Adults diagnosed with obesity. Adults who are overweight and have at least one weight-related medical condition, such as diabetes, hypertension, or cardiovascular disease. The SFDA emphasized that the medication should be used alongside<\/p>\n","protected":false},"author":1,"featured_media":57937,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[13151],"tags":[],"class_list":["post-57936","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"yoast_head":"<!-- This site is optimized with the Yoast SEO 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